Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis

Arthritis Rheum. 1993 Feb;36(2):199-203. doi: 10.1002/art.1780360209.


Objective: To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA).

Methods: Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated.

Results: Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain.

Conclusion: These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / pathology*
  • Arthritis, Rheumatoid / physiopathology
  • Arthritis, Rheumatoid / psychology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Receptors, Interleukin-2 / analysis*
  • Solubility
  • Stress, Psychological / blood
  • Stress, Psychological / pathology*
  • Time Factors


  • Receptors, Interleukin-2