Bone mineral density of the hip and of the anteroposterior and lateral dimensions of the spine in men with rheumatoid arthritis. Effects of low-dose corticosteroids

Arthritis Rheum. 1993 Feb;36(2):222-8. doi: 10.1002/art.1780360213.


Objective: To assess bone mineral density (BMD) in men with steroid-treated rheumatoid arthritis (RA).

Methods: Dual-energy x-ray absorptiometry (DXA) was used to measure BMD in 40 men with RA, 20 of whom were receiving low-dose corticosteroids (< or = 10 mg prednisolone daily), and in 20 healthy, age-matched male controls.

Results: BMD was significantly reduced at the femoral neck and greater trochanter in both groups of RA patients, and at the spine from the anteroposterior dimension in the steroid-treated group.

Conclusion: Low-dose steroid therapy may induce excess axial osteopenia in men with RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Aged
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / metabolism*
  • Arthritis, Rheumatoid / physiopathology
  • Bone Density / drug effects
  • Bone Density / physiology*
  • Dose-Response Relationship, Drug
  • Hip Joint / chemistry*
  • Humans
  • Male
  • Middle Aged
  • Prednisolone / administration & dosage
  • Prednisolone / therapeutic use
  • Spine / chemistry*


  • Adrenal Cortex Hormones
  • Prednisolone