Doxorubicin hydrochloride-associated renal failure

Arch Intern Med. 1977 Mar;137(3):385-8.


Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to those seen following administration of structural analogues of doxorubicin. Daunorubicin hydrochloride, particularly, is known to cause renal failure in experimental animals. Renal function should be monitored in patients receiving doxorubicin.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / pathology
  • Aged
  • Bronchial Neoplasms / drug therapy
  • Carcinoma, Squamous Cell / drug therapy
  • Daunorubicin / adverse effects
  • Doxorubicin / adverse effects*
  • Doxorubicin / therapeutic use
  • Humans
  • Kidney Glomerulus / ultrastructure
  • Male


  • Doxorubicin
  • Daunorubicin