Primary T-cell lymphoma of the gastrointestinal tract associated with human T-cell lymphotropic virus type I. An analysis using in situ hybridization and polymerase chain reaction

Cancer. 1993 Feb 1;71(3):708-16. doi: 10.1002/1097-0142(19930201)71:3<708::aid-cncr2820710309>;2-p.


Background: During a population-based local cancer registry, a peculiar type of T-cell lymphoma restricted to the gastrointestinal tract was found in patients living in southwestern Japan.

Methods: Five cases of gastrointestinal (GI) tract T-cell lymphoma were analyzed with immunohistologic examination, ultrastructural analysis, in situ hybridization (ISH), and polymerase chain reaction (PCR).

Results: All cases satisfied the criteria of primary GI tract lymphoma at presentation or operation. Four showed a close relationship to human T-cell lymphotropic virus type I (HTLV-I). Those four had positive results for anti-HTLV-I antibody and positive surface markers for CD4, positive hybridization signals by ISH, and HTLV-I gene products by PCR, but they had no lymphoma cells in peripheral blood or bone marrow. The fifth case showed negative signals by ISH and PCR.

Conclusions: These findings suggest that some of the putative adult T-cell leukemia/lymphoma (ATLL) types can be further classified as GI-tract-type lymphoma. The prognosis for the GI tract type is as poor as it is for conventional ATLL.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Base Sequence
  • DNA Probes
  • Female
  • Gastrointestinal Neoplasms / microbiology*
  • Gastrointestinal Neoplasms / pathology
  • HTLV-I Antibodies / analysis
  • HTLV-I Infections / genetics
  • HTLV-I Infections / immunology
  • Human T-lymphotropic virus 1 / genetics*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization*
  • Lymphoma, T-Cell / metabolism*
  • Lymphoma, T-Cell / pathology
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction*


  • DNA Probes
  • HTLV-I Antibodies