t(5;12)(q31;p12). A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia

Cancer Genet Cytogenet. 1993 Jan;65(1):7-11. doi: 10.1016/0165-4608(93)90051-m.

Abstract

We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into one of the well-defined entities of either MPD or myelodysplastic disorders. We postulate that this translocation may represent a subgroup of patients with features of both chronic myeloid leukemia and chronic myelomonocytic leukemia (CMMoL).

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Blotting, Southern
  • Chromosomes, Human, Pair 12*
  • Chromosomes, Human, Pair 5*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics*
  • Leukemia, Myelomonocytic, Chronic / genetics*
  • Male
  • Middle Aged
  • Translocation, Genetic*