Development of a device for measuring adherence of skin grafts to the wound surface

Ann Biomed Eng. 1993;21(1):51-5. doi: 10.1007/BF02368164.

Abstract

Adherence of a biological graft to the wound surface is the most important factor influencing the ultimate success of graft viability. A machine has been developed to test the adherence of biological graft materials to a substrate such as a wound surface. The peeling mode, which yields reproducible quantitative measurements of adherence, is a standard method for testing adhesives. The device is designed to continuously measure the force required to peel the graft from the substrate at a constant rate. This force is a function of the energy of adhesion per unit area of adhered surface. This device has been used to measure the peeling force of (2 x 2 cm) skin grafts which are applied to full-thickness wounds on mice. Results of tests on adherence of autografts on mice show that the peeling force increases significantly with time over the first 9 days of healing. Thus, this device is useful in quantitative comparison of various skin grafting techniques and artificial grafts.

MeSH terms

  • Adhesiveness
  • Animals
  • Biomechanical Phenomena
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Materials Testing / instrumentation*
  • Mice
  • Skin Transplantation / standards*
  • Time Factors
  • Wound Healing
  • Wounds and Injuries / physiopathology
  • Wounds and Injuries / therapy*