Signal loss in the motor cortex on magnetic resonance images in amyotrophic lateral sclerosis

Ann Neurol. 1993 Feb;33(2):218-22. doi: 10.1002/ana.410330214.


Three of 7 patients with amyotrophic lateral sclerosis had bilateral signal loss confined to the motor cortex on T2-weighted magnetic resonance images. None of the control subjects had this abnormality. Although not present in every patient, this finding might reflect the primary pathological process of the motor cortex in amyotrophic lateral sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amyotrophic Lateral Sclerosis / diagnosis*
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Motor Cortex / pathology*
  • Reference Values