Androgen receptor and mechanism of androgen action

Ann Med. 1993 Feb;25(1):83-9. doi: 10.3109/07853899309147863.


Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner. The present overview describes the structurally important domains of the receptor protein, and discusses several aspects in the structure-function relationship, using naturally occurring receptor mutants in androgen insensitivity patients or experimental animals as examples. In addition, characteristics of androgen receptor expressed in a heterologous system are described, and their potential usefulness in specific molecular studies discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Androgens / physiology*
  • Animals
  • Baculoviridae / genetics
  • Gene Expression
  • Humans
  • Male
  • Receptors, Androgen* / genetics
  • Receptors, Androgen* / physiology
  • Transcriptional Activation


  • Androgens
  • Receptors, Androgen