Ophthalmic artery flow velocity in glaucomatous and normal subjects

Br J Ophthalmol. 1993 Jan;77(1):25-9. doi: 10.1136/bjo.77.1.25.


The velocity of blood flow in the ophthalmic artery was measured with a transcranial Doppler ultrasound (2 MHz). Sixty patients with chronic open angle glaucoma (COAG), 42 patients with normal tension glaucoma (NTG), and 35 normals were studied. Peak flow velocity (peak), mean-enveloped velocity (mean) and diastolic velocity were compared in the three groups. The COAG patients and the NTG patients showed a significant reduction of all three Doppler flow velocities compared with the normals (COAG vs normal, p = 0.013, 0.019, and 0.009; NTG vs normal, p = < 0.001, < 0.001, and < 0.001 for peak, mean and diastolic flow velocity respectively). The NTG patients also had a significant slower mean flow velocity than the COAG patients (p = 0.016), but not for peak and diastolic flow velocities (p = 0.060 and 0.052 respectively). Based on ophthalmic flow velocity values, many NTG patients and a few COAG patients had slower flow velocities than the normals. The significance of these haemodynamic differences is not yet known.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Flow Velocity
  • Female
  • Glaucoma / diagnostic imaging
  • Glaucoma / drug therapy
  • Glaucoma / physiopathology*
  • Glaucoma, Open-Angle / diagnostic imaging
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Artery / diagnostic imaging
  • Ophthalmic Artery / physiopathology*
  • Ultrasonography