Effects of mazindol on behavior maintained or occasioned by cocaine

Drug Alcohol Depend. 1993 Jan;31(2):183-91. doi: 10.1016/0376-8716(93)90071-w.


The effects of mazindol, cocaine and D-amphetamine were studied in rhesus monkeys trained to self-administer cocaine, and in rats and squirrel monkeys trained to discriminate cocaine from saline. Non-contingent intravenous drug injections were administered to monkeys responding under a session consisting of a 5-min period during which lever-pressing produced food reinforcement and a 60-min session in which responding produced i.v. cocaine infusions (10 or 33 micrograms/kg per infusion). Acute i.v. injections of cocaine (0.1-1.7 mg/kg), D-amphetamine (0.1-1 mg/kg) and the dopamine re-uptake inhibitor mazindol (0.03-0.56 mg/kg) given 5 min before the session decreased self-administration of cocaine, but also decreased rates of behavior maintained by the presentation of food. In both rats and squirrel monkeys trained to discriminate cocaine from saline in a two-lever, food-maintained procedure, mazindol, cocaine and D-amphetamine substituted for cocaine in a dose-related manner. Despite a lack of selectivity to decrease cocaine self-administration as compared to behavior maintained by food, the present data provide some rationale for further consideration of mazindol as a potential pharmacotherapy for stimulant abuse, due to its relatively low abuse liability and cocaine-like discriminative stimulus effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Appetitive Behavior / drug effects
  • Arousal / drug effects*
  • Behavior, Animal / drug effects*
  • Cocaine / administration & dosage*
  • Dextroamphetamine / pharmacology
  • Discrimination Learning / drug effects
  • Dose-Response Relationship, Drug
  • Female
  • Macaca mulatta
  • Male
  • Mazindol / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Reinforcement Schedule
  • Saimiri
  • Self Administration


  • Mazindol
  • Cocaine
  • Dextroamphetamine