Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae

Mol Gen Genet. 1993 Jan;236(2-3):363-8. doi: 10.1007/BF00277134.


The ENA2 gene encoding a P-type ATPase involved in Na+ and Li+ effluxes in Saccharomyces cerevisiae has been isolated. The putative protein encoded by ENA2 differs only in thirteen amino acids from the protein encoded by ENA1/PMR2. However, ENA2 has a very low level of expression and for this reason did not confer significant Li+ tolerance on a Li+ sensitive strain. ENA1 and ENA2 are the first two units of a tandem array of four highly homologous genes with probably homologous functions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Base Sequence
  • DNA, Recombinant
  • Drug Resistance, Microbial
  • Gene Expression Regulation, Enzymologic*
  • Genes, Fungal / genetics*
  • Isoenzymes / genetics*
  • Lac Operon / genetics
  • Lithium / metabolism
  • Lithium / pharmacology
  • Molecular Sequence Data
  • Plasmids / genetics
  • Saccharomyces cerevisiae / genetics*
  • Sodium / metabolism*


  • DNA, Recombinant
  • Isoenzymes
  • Lithium
  • Sodium
  • Adenosine Triphosphatases

Associated data

  • GENBANK/X67136