Pregnancy outcome following a second-trimester loss

Obstet Gynecol. 1993 Mar;81(3):444-6.


Objective: To evaluate the association between fetal loss in the second trimester and subsequent adverse birth outcomes.

Methods: We identified 95 women in our system who had a pregnancy loss at 13-24 weeks in the years 1985-1990 and tabulated the rates of preterm delivery, stillbirth, and neonatal death in the next pregnancy. We compared these outcomes to two groups: women who delivered at 25-36 weeks in their index pregnancy and those who delivered at term in their index pregnancy.

Results: Thirty-nine percent of women who had a pregnancy loss at 13-24 weeks in the index pregnancy had a preterm delivery in their next pregnancy, 5% had a stillbirth, and 6% had a neonatal death, with all outcomes worse than those found in the two control populations. Delivery at 19-22 weeks in the index pregnancy was associated with a 62% preterm delivery rate in the subsequent pregnancy.

Conclusion: A second-trimester loss, especially one occurring at 19-22 weeks, is associated with a poor prognosis in the subsequent pregnancy.

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Adult
  • Female
  • Fetal Death / epidemiology*
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Obstetric Labor, Premature / epidemiology*
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Pregnancy Trimester, Second
  • Prognosis
  • Retrospective Studies
  • Risk Factors