Strongyloidiasis is a parasitic disease which occurs not only in tropical regions, but to some extent in the South of Europe. Diagnosis is often difficult because of a polymorphic clinical picture and low larvae excretion in the stool. A case of an Italian patient suffering from a long-standing intestinal strongyloidiasis is reported. Diagnosis was made only after a long time and after a couple of superfluous examinations. Several treatment attempts were necessary to eradicate the infection.