Growth and body composition of periurban Guatemalan children in relation to zinc status: a longitudinal zinc intervention trial

Am J Clin Nutr. 1993 Mar;57(3):344-52. doi: 10.1093/ajcn/57.3.344.

Abstract

Changes in growth, body composition, and zinc indexes were evaluated after 25 wk in a double-blind zinc-supplementation study of 162 periurban Guatemalan children aged 81.5 +/- 7.0 mo (mean +/- SD). Children receiving the zinc supplement (10 mg Zn/d as amino acid chelate) for 90.1 +/- 9.2 d had higher mean fasting plasma zinc (16.2 +/- 2.9 vs 14.9 +/- 2.1 mumol/L, P < 0.01), a greater increase in median triceps skinfold Z score (0.50 vs 0.38, P < 0.05), and a smaller deficit in median midarm circumference (MAC) Z score (-0.03 vs -0.20, P < 0.05) compared with the placebo group. Initial hair zinc classified as < 1.68 and > 1.68 mumol/g was the only laboratory variable that explained some of the variance in final Z scores of midarm-muscle area (P < 0.05) and MAC (P < 0.01). Children responded to the zinc supplement with changes in indexes of body composition rather than growth.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Body Composition*
  • Child
  • Cognition
  • Double-Blind Method
  • Female
  • Growth*
  • Guatemala
  • Hair / chemistry
  • Humans
  • Male
  • Nutritional Status*
  • Placebos
  • Skinfold Thickness
  • Zinc / administration & dosage
  • Zinc / analysis
  • Zinc / deficiency*

Substances

  • Placebos
  • Zinc