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, 290 ( Pt 1) (Pt 1), 205-18

Evolutionary Families of Peptidases

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Evolutionary Families of Peptidases

N D Rawlings et al. Biochem J.

Abstract

The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in 'clans' that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.

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References

    1. Philos Trans R Soc Lond B Biol Sci. 1970 Feb 12;257(813):77-87 - PubMed
    1. Plant Mol Biol. 1990 Jul;15(1):11-26 - PubMed
    1. Nature. 1992 Apr 30;356(6372):768-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4693-7 - PubMed
    1. Biochem J. 1992 May 1;283 ( Pt 3):647-8 - PubMed

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