Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 290 ( Pt 1) (Pt 1), 205-18

Evolutionary Families of Peptidases


Evolutionary Families of Peptidases

N D Rawlings et al. Biochem J.


The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in 'clans' that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.

Similar articles

See all similar articles

Cited by 174 PubMed Central articles

See all "Cited by" articles


    1. Philos Trans R Soc Lond B Biol Sci. 1970 Feb 12;257(813):77-87 - PubMed
    1. Plant Mol Biol. 1990 Jul;15(1):11-26 - PubMed
    1. Nature. 1992 Apr 30;356(6372):768-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4693-7 - PubMed
    1. Biochem J. 1992 May 1;283 ( Pt 3):647-8 - PubMed

LinkOut - more resources