Elimination diet and intestinal permeability in atopic eczema: a preliminary study

Clin Exp Allergy. 1993 Jan;23(1):28-31. doi: 10.1111/j.1365-2222.1993.tb02480.x.


We measured small intestinal permeability to lactulose and rhamnose in 18 healthy children and in 15 children with atopic eczema, before and after a 14-day elimination diet. The children with atopic eczema had higher initial urinary lactulose/rhamnose ratios than the controls. After dietary restriction, there was no overall change in permeability. Dietary therapy did however result in a large reduction in permeability in three of the nine children whose skin disease was improved, but a statistically significant decrease in permeability was not observed in the diet-responsive group as a whole. Larger studies would be required to confirm that dietary restrictions can reduce intestinal permeability in some children with atopic eczema.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Dermatitis, Atopic / diet therapy
  • Dermatitis, Atopic / metabolism*
  • Dermatitis, Atopic / urine
  • Female
  • Food Hypersensitivity / diagnosis
  • Gastric Emptying / physiology
  • Gastrointestinal Transit / physiology
  • Humans
  • Immunoglobulin E / blood
  • Infant
  • Intestinal Absorption / physiology*
  • Lactulose / pharmacokinetics
  • Lactulose / urine
  • Male
  • Radioallergosorbent Test
  • Rhamnose / pharmacokinetics
  • Rhamnose / urine


  • Immunoglobulin E
  • Lactulose
  • Rhamnose