Inhibition of the immune response by rapamycin, a new antifungal antibiotic

Can J Physiol Pharmacol. 1977 Feb;55(1):48-51. doi: 10.1139/y77-007.

Abstract

Rapamycin, a new antifungal antibiotic, was found to inhibit the immune response in rats. It totally prevented the development of two experimental immunopathies (experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)) and the formation of humoral (IgE-like) antibody. It was about half as potent as cyclophosphamide in inhibiting EAE. In AA and on antibody formation, rapamycin and cyclophosphamide were about equipotent, whereas methotrexate was more potent. The immunosuppressant activity of rapamycin appears to be related to inhibition of the lymphatic system.

MeSH terms

  • Animals
  • Antibody Formation / drug effects*
  • Antifungal Agents / pharmacology*
  • Arthritis / drug therapy*
  • Arthritis, Experimental / drug therapy*
  • Cyclophosphamide / pharmacology
  • Dose-Response Relationship, Drug
  • Encephalomyelitis, Autoimmune, Experimental / drug therapy*
  • Female
  • Immunoglobulin E / biosynthesis
  • Methotrexate / pharmacology
  • Polyenes / pharmacology
  • Rats

Substances

  • Antifungal Agents
  • Polyenes
  • Immunoglobulin E
  • Cyclophosphamide
  • Methotrexate