Differential expression of the insulin-like growth factor II and transthyretin genes in the developing rat choroid plexus

J Neuropathol Exp Neurol. 1993 Mar;52(2):153-62. doi: 10.1097/00005072-199303000-00008.


Choroid plexus (CP) development may depend on an inductive interaction between primordial CP epithelium and the overlying mesenchyme. Expression of the two CP epithelial-expressed genes, transthyretin (TTR) and insulin-like growth factor II (IGF-II), were studied by in situ hybridization in the developing rat. Transthyretin mRNA is expressed in abundance in the primordial CP epithelium prior to CP morphogenesis (e10-11) but IGF-II mRNA expression begins later (e13) and increases gradually as morphogenesis proceeds. In the CP stroma (mesenchyme), IGF-II mRNA is abundant prior to CP morphogenesis but decreases as embryogenesis proceeds and is absent in the adult. Our findings suggest that IGF-II may play an early paracrine and later autocrine role in CP development. A model is proposed in which IGF-II synthesized by mesenchyme serves as an inducing principle for CP epithelial differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Differentiation
  • Choroid Plexus / cytology
  • Choroid Plexus / embryology*
  • Choroid Plexus / physiology
  • Embryonic and Fetal Development
  • Female
  • Gene Expression
  • Gestational Age
  • In Situ Hybridization
  • Insulin-Like Growth Factor II / genetics*
  • Morphogenesis
  • Prealbumin / genetics*
  • Pregnancy
  • RNA Probes
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Sprague-Dawley


  • Prealbumin
  • RNA Probes
  • RNA, Messenger
  • Insulin-Like Growth Factor II