Update on artificial sweeteners and bladder cancer

Regul Toxicol Pharmacol. 1993 Feb;17(1):35-43. doi: 10.1006/rtph.1993.1004.


Review of the most recent epidemiologic studies indicates there is no detectable association between artificial sweetener consumption and bladder cancer. The summary relative risk from a meta-analysis of all case-control studies approaches unity (RR .97). This analysis, in combination with new evidence for a unique mechanism of saccharin carcinogenicity in the male rat, leads to the conclusion that saccharin is not related to bladder cancer in humans.

Publication types

  • Meta-Analysis

MeSH terms

  • Animals
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Rats
  • Risk Factors
  • Saccharin / adverse effects*
  • Saccharin / analogs & derivatives
  • Sex Factors
  • Species Specificity
  • Urinary Bladder Neoplasms / chemically induced*
  • Urinary Bladder Neoplasms / epidemiology


  • Saccharin