Stewart's quantitative acid-base chemistry: applications in biology and medicine

Respir Physiol. 1993 Jan;91(1):1-16. doi: 10.1016/0034-5687(93)90085-o.


We review P.A. Stewart's quantitative approach to acid-base chemistry, starting with its historical context. We outline its implications for cellular and membrane processes in acid-base physiology; discuss its contributions to the understanding and analysis of acid-base phenomena; show how it can be applied in clinical problems; and propose a classification of clinical acid-base disturbances based on this general approach.

Publication types

  • Review

MeSH terms

  • Acid-Base Equilibrium / physiology*
  • Acid-Base Imbalance / classification
  • Acid-Base Imbalance / physiopathology
  • Biological Transport / physiology
  • Cell Membrane / physiology
  • Humans