[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica]

Wien Klin Wochenschr. 1993;105(2):61-3.
[Article in German]

Abstract

A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Diazepam / administration & dosage
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Haloperidol / administration & dosage
  • Humans
  • Malaria, Falciparum / drug therapy*
  • Male
  • Mefloquine / administration & dosage
  • Mefloquine / poisoning*
  • Psychoses, Substance-Induced / drug therapy
  • Psychoses, Substance-Induced / etiology*
  • Pyrimethamine / administration & dosage
  • Pyrimethamine / poisoning*
  • Sulfadoxine / administration & dosage
  • Sulfadoxine / poisoning*
  • Thioridazine / administration & dosage

Substances

  • Sulfadoxine
  • Haloperidol
  • Thioridazine
  • Diazepam
  • Mefloquine
  • Pyrimethamine