Mode of ascertainment is critical in assessing safety of percutaneous umbilical blood sampling

Am J Perinatol. 1993 Jan;10(1):27-9. doi: 10.1055/s-2007-994695.

Abstract

Percutaneous umbilical blood sampling (PUBS) is increasingly utilized for cytogenetic assessment of the fetus. In the present study, outcome of 109 PUBS-derived fetal blood samples were analyzed according to mode of ascertainment: ultrasound-detected anatomic anomalies or intrauterine growth retardation (IUGR). Abnormal chromosome complements were found in 6 of 47 (12.8%) fetuses with anomalies but in only 1 of 62 (1.6%) fetuses with IUGR alone. Perinatal loss in fetuses with anatomic anomalies was 64.4%, compared with only 1.6% in fetuses with IUGR alone. Mode of patient ascertainment is an important factor that must be considered in determining procedure-related risks for PUBS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Specimen Collection / methods
  • Chromosome Aberrations / diagnosis*
  • Chromosome Disorders
  • Congenital Abnormalities / diagnostic imaging
  • Female
  • Fetal Blood*
  • Fetal Diseases / genetics*
  • Fetal Growth Retardation / diagnostic imaging
  • Humans
  • Pregnancy
  • Prenatal Diagnosis / adverse effects
  • Prenatal Diagnosis / methods*
  • Risk Factors
  • Safety
  • Ultrasonography, Prenatal