Synovial copper deposition as a possible explanation of arthropathy in Wilson's disease

U Kramer; A Weinberger; R Yarom; J Zoldan; A Bahar; N Godoth

Synovial copper deposition as a possible explanation of arthropathy in Wilson's disease

Bull Hosp Jt Dis. 1993 Winter;52(2):46-9.

Authors

U Kramer¹, A Weinberger, R Yarom, J Zoldan, A Bahar, N Godoth

Affiliation

¹ Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.

PMID: 8443556

Abstract

A patient with longstanding Wilson's disease and arthritis is presented. Synovial biopsy disclosed thickening of the membrane, intimal histiocytes, and lymphocyte infiltration without pigmentation. X-ray energy spectroscopy demonstrated copper and iron in high concentrations. These findings may contribute to our understanding of the development of the arthropathy in patients with Wilson's disease.

Publication types

Case Reports
Review

MeSH terms

Arthritis / diagnostic imaging
Arthritis / etiology
Arthritis / pathology*
Biopsy
Copper / chemistry*
Electron Probe Microanalysis
Female
Hepatolenticular Degeneration / complications*
Hepatolenticular Degeneration / diagnosis
Hepatolenticular Degeneration / metabolism
Humans
Hyperplasia
Inflammation
Middle Aged
Radiography
Spectrometry, X-Ray Emission
Synovial Membrane / chemistry*
Synovial Membrane / pathology

Substances

Copper