Modulatory influence of sandalwood oil on mouse hepatic glutathione S-transferase activity and acid soluble sulphydryl level

Cancer Lett. 1993 Feb;68(2-3):105-9. doi: 10.1016/0304-3835(93)90135-v.

Abstract

The effect of the oil from the wood of Santalum album on glutathione S-transferase (GST) activity and acid soluble sulphydryl (SH) levels in the liver of adult male Swiss albino mice was investigated. Oral feeding by gavage to mice each day with 5 and 15 microliters sandalwood oil for 10 and 20 days exhibited an increase in GST activity in time- and dose-responsive manners. Feeding a dose of 5 microliters sandalwood oil for 10 and 20 days caused, respectively, a 1.80-fold (P < 0.001) and 1.93-fold (P < 0.001) increase in GST enzyme activity, while feeding a dose of 15 microliters of the oil per day for 10 and 20 days induced, respectively, 4.73-fold (P < 0.001) and 6.10-fold (P < 0.001) increases in the enzyme's activity. In addition, there were 1.59-fold (P < 0.001) and 1.57 (P < 0.001) increases in acid-soluble SH levels in the hepatic tissue of the mice following feeding of the oil at the dose levels of 5 and 15 microliters for 10 days. Furthermore, mice fed on a diet containing 1% 2(3)-butyl-4-hydroxyanisole (positive control) also showed an increase in hepatic GST activity and SH levels. Enhancement of GST activity and acid-soluble SH levels are suggestive of a possible chemopreventive action of sandalwood oil on carcinogenesis through a blocking mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Butylated Hydroxyanisole / pharmacology
  • Dietary Fats, Unsaturated / pharmacology*
  • Dose-Response Relationship, Drug
  • Glutathione Transferase / metabolism*
  • Liver / metabolism*
  • Male
  • Mice
  • Plant Oils / pharmacology*
  • Sulfhydryl Compounds / metabolism*
  • Time Factors

Substances

  • Dietary Fats, Unsaturated
  • Plant Oils
  • Sulfhydryl Compounds
  • Butylated Hydroxyanisole
  • Glutathione Transferase