Colonic mucosal pH in humans

Dig Dis Sci. 1993 Mar;38(3):542-5. doi: 10.1007/BF01316512.


Mucosal pH was measured at specific anatomic segments within the colon using a flexible pH probe in patients prepared for colonoscopy. The data revealed similar pH measurements along the length of the colon, irrespective of the presence or absence of colorectal neoplasia. Patients exhibited a relatively acidic right colon; a more alkaline transverse, left, and sigmoid colon; and a relatively acidic rectum. There were no apparent gender- or age-related effects on colonic mucosal pH.

Publication types

  • Comparative Study

MeSH terms

  • Colon / metabolism*
  • Colonic Neoplasms / metabolism*
  • Colonoscopy
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Intestinal Mucosa / metabolism*
  • Male
  • Middle Aged