The immune response in iron-deficient young children: effect of iron supplementation on cell-mediated immunity

Eur J Pediatr. 1993 Feb;152(2):120-4. doi: 10.1007/BF02072487.

Abstract

The effects of iron deficiency on immunity remain controversial. This study was designed to assess the impact of iron supplementation on the immune status, in 81 children aged 6 months-3 years, at high risk for iron deficiency, using a longitudinal double blind randomised and placebo-controlled study. Lymphocytes of iron-deficient children produced less interleukin-2 in vitro. Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity. The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Hypochromic / blood
  • Anemia, Hypochromic / drug therapy
  • Anemia, Hypochromic / immunology*
  • Child, Preschool
  • Double-Blind Method
  • Erythrocyte Indices / drug effects
  • Female
  • Ferritins / blood
  • Humans
  • Immunity, Cellular / drug effects
  • Immunoglobulins / blood
  • Infant
  • Interleukin-2 / blood
  • Iron / deficiency
  • Iron / pharmacology
  • Iron / therapeutic use*
  • Longitudinal Studies
  • Male
  • T-Lymphocyte Subsets / immunology
  • Transferrin / analysis

Substances

  • Immunoglobulins
  • Interleukin-2
  • Transferrin
  • Ferritins
  • Iron