Proliferation and differentiation of tumour cells from B-cell lymphoma of mucosa-associated lymphoid tissue in vitro

J Pathol. 1993 Feb;169(2):221-7. doi: 10.1002/path.1711690208.


Several characteristics of lymphomas of mucosa-associated lymphoid tissue (MALT type) suggest that they are antigen-dependent and that their growth parodies a normal immune response. We have previously shown that three cases of low-grade B-cell MALT-type lymphoma recognize autoantigens. In this study, we investigated the response of three low-grade and one high-grade case of MALT-type lymphoma to anti-idiotypic antibody as a model of antigen binding either alone or as a co-stimulus with B-cell mitogens. We also studied the response of tumour cells to interleukin-6 (IL-6), which induces differentiation to immunoglobulin-producing cells in many systems. Of the four cases studied, one low-grade case showed markedly enhanced proliferation in response to anti-idiotype alone. This could not be increased by the addition of mitogens. In the remaining two low-grade cases, mitogen responsiveness was observed which was affected by anti-idiotype either by an enhancement or by a reduction in the proliferative response. The high-grade case failed to respond to the stimuli studied. No response to IL-6 was observed. This study supports the suggestion that antigen may affect the pathogenesis of low-grade tumours of MALT type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anti-Idiotypic / metabolism*
  • Cell Differentiation / drug effects
  • Cell Division / immunology
  • Humans
  • Immunoglobulins / biosynthesis
  • Interleukin-6 / pharmacology
  • Lymphoid Tissue / pathology
  • Lymphoma, B-Cell / immunology
  • Lymphoma, B-Cell / pathology*
  • Mucous Membrane / immunology
  • Tumor Cells, Cultured / drug effects


  • Antibodies, Anti-Idiotypic
  • Immunoglobulins
  • Interleukin-6