Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study

Ophthalmic Surg. 1993 Jan;24(1):24-7.


We measured aqueous flare in 16 glaucomatous eyes after trabeculectomy in which 5-fluorouracil (5-FU) or mitomycin C (MMC) had been used as an adjunctive therapy. The eyes were divided into a 5-FU and an MMC group, matched for factors that might influence the postoperative inflammatory response to intraocular surgery. Seven eyes of seven patients received subconjunctival injections of 5-FU (50 mg in 2 weeks) and nine eyes of nine patients were given 0.2 mg/0.5 mL MMC intraoperatively. The aqueous flare converted to an albumin concentration (mg/dL) was significantly higher in the 5-FU group than in the MMC group (359.6 +/- 113.8 mg/dL and 143.2 +/- 46.7 mg/dL, respectively; Mann-Whitney U test, P < .05) on the second postoperative day. Intraoperative MMC appears to be no more harmful to the blood-aqueous barrier than 5-FU.

Publication types

  • Comparative Study

MeSH terms

  • Anterior Chamber / drug effects*
  • Aqueous Humor / metabolism*
  • Biological Transport, Active
  • Blood / metabolism
  • Chemotherapy, Adjuvant
  • Eye Proteins / metabolism
  • Female
  • Fluorouracil / therapeutic use*
  • Glaucoma / surgery
  • Humans
  • Injections
  • Intraocular Pressure / drug effects
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use*
  • Trabeculectomy*


  • Eye Proteins
  • Mitomycin
  • Fluorouracil