Appropriate treatment of musculoskeletal neoplasms relies on prompt and accurate identification of tumor characteristics and extent. Multiplanar and three-dimensional (3-D) computed tomography (CT) provide rapid, relatively noninvasive imaging for initial assessment and for planning of radiation therapy, en bloc resection, and limb-salvage surgery. An integrated 2-D-3-D CT approach also allows precise tracking of therapeutic response and recurrence.