We retrospectively reviewed the records, photographs, and fluorescein angiograms of patients with chorioretinal folds to compare features of unilateral and bilateral involvement. We studied 78 eyes of 54 patients and found that 30 (56%) of these patients had unilateral folds and 24 (44%) had bilateral folds. No significant difference was found in comparing visual acuity, refractive error, age, or race in the unilateral vs the bilateral cases. There were significantly more women in the bilateral group (P = .043). The frequency of causes of unilateral cases differed from bilateral cases, but this could not be statistically proven owing to our small sample size. This analysis contains the largest number of chorioretinal folds reported in the literature, and is the first attempt to compare unilateral and bilateral cases.