Mixed haplotypes and autoimmunity

Immunol Today. 1993 Feb;14(2):53-6. doi: 10.1016/0167-5699(93)90058-s.

Abstract

Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology
  • Crosses, Genetic
  • Exons
  • Genes, MHC Class II*
  • H-2 Antigens / genetics
  • H-2 Antigens / immunology
  • Haplotypes / genetics*
  • Haplotypes / immunology
  • Histocompatibility Antigens Class II / genetics*
  • Histocompatibility Antigens Class II / immunology
  • Lupus Erythematosus, Systemic / genetics*
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Nephritis / genetics
  • Lupus Nephritis / immunology
  • Mice
  • Mice, Inbred NZB / genetics*
  • Mice, Inbred NZB / immunology
  • Models, Genetic*
  • Molecular Sequence Data

Substances

  • H-2 Antigens
  • Histocompatibility Antigens Class II
  • I-E-antigen