Intermediate filament structure and assembly

Curr Opin Cell Biol. 1993 Feb;5(1):3-11. doi: 10.1016/s0955-0674(05)80002-x.


Intermediate filaments are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice. Filament structure and assembly can be influenced at several different structural levels, including molecular structure, oligomer formation and filament nucleation and elongation. Consequently, it can sometimes be difficult to interpret mutagenesis data unequivocally, although regions near the amino and carboxyl termini of the rod domain of the molecule are known to be important for the production of native filaments. Imperfections in molecular packing may be important in filament assembly and dynamics.

Publication types

  • Review

MeSH terms

  • Animals
  • Intermediate Filament Proteins / genetics
  • Intermediate Filament Proteins / metabolism
  • Intermediate Filaments / metabolism
  • Intermediate Filaments / ultrastructure*
  • Lamins
  • Mutagenesis
  • Nuclear Proteins / metabolism
  • Phenotype


  • Intermediate Filament Proteins
  • Lamins
  • Nuclear Proteins