Possible Interaction Between Fluoxetine and Pimozide Causing Sinus Bradycardia

Can J Psychiatry. 1993 Feb;38(1):62-3. doi: 10.1177/070674379303800116.

Abstract

Fluoxetine has been reported to have interactions with antipsychotics and other antidepressants with symptoms of toxicity of these drugs. We report a case of a possible interaction with pimozide which led to a potentially life threatening bradycardia. Careful monitoring should be done when these two drugs are prescribed at the same time, especially in the elderly and in patients with cardiac disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Arrhythmia, Sinus / chemically induced*
  • Bradycardia / chemically induced*
  • Delusions / drug therapy
  • Delusions / psychology
  • Dementia / drug therapy*
  • Dementia / psychology
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / psychology
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Therapy, Combination
  • Electrocardiography / drug effects
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / drug therapy*
  • Obsessive-Compulsive Disorder / psychology
  • Paranoid Disorders / drug therapy
  • Paranoid Disorders / psychology
  • Pimozide / adverse effects*
  • Pimozide / therapeutic use

Substances

  • Fluoxetine
  • Pimozide