HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis

J Intern Med. 1993 Mar;233(3):281-6. doi: 10.1111/j.1365-2796.1993.tb00988.x.


Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Cholangitis, Sclerosing / complications
  • Cholangitis, Sclerosing / genetics*
  • Colitis, Ulcerative / complications
  • Colitis, Ulcerative / genetics*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / genetics*
  • HLA-DQ Antigens / genetics*
  • HLA-DR3 Antigen / genetics*
  • Homozygote
  • Humans
  • Male


  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-DR3 Antigen