Bisbenzylisoquinoline alkaloids inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin

Oncology. Mar-Apr 1993;50(2):137-40. doi: 10.1159/000227165.

Abstract

Bisbenzylisoquinoline alkaloids, cepharanthine, berbamine and isotetrandrine, were isolated from Stephania cepharantha Hayata. These compounds inhibit arachidonic acid-induced inflammation in mice. We have found that cepharanthine inhibits tumor promotion after topical application and oral administration in two-stage carcinogenesis in mouse skin. Furthermore, topical application of berbamine (2 mumol/mouse) and isotetrandrine (2 mumol/mouse) markedly suppressed the tumor-promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram) in mouse skin initiated with 7,12-dimethylbenz[a]anthracene (50 micrograms), at a grade corresponding to that of cepharanthine.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Administration, Topical
  • Alkaloids / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Anticarcinogenic Agents / therapeutic use*
  • Antineoplastic Agents / therapeutic use
  • Arachidonic Acid
  • Benzylisoquinolines*
  • Female
  • Inflammation / chemically induced
  • Inflammation / prevention & control
  • Isoquinolines / therapeutic use*
  • Mice
  • Mice, Inbred ICR
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control*
  • Tetradecanoylphorbol Acetate / pharmacology*

Substances

  • Alkaloids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Benzylisoquinolines
  • Isoquinolines
  • Arachidonic Acid
  • tetrandrine
  • 9,10-Dimethyl-1,2-benzanthracene
  • cepharanthine
  • Tetradecanoylphorbol Acetate
  • berbamine