There have been many studies suggesting that locomotion on a treadmill tends to be different than locomotion at similar velocities overground, but no satisfactory mechanical or neural mechanisms to account for the differences have been identified. The most prominent difference is the tendency to adopt a pacing gait for both walking and trotting speeds, in which the legs on one side of the body move in phase as lateral couplets rather than the typical diagonal couplet pattern seen overground. Using conventional video analysis, we quantified the gait patterns of intact, adult cats walking at various speeds overground and in a motorized treadmill. We noted that cats paced most frequently when they were at the front end of the treadmill enclosure, and that this gait was associated with an extended stride length that permitted the animals to maintain a higher duty factor of support (mean number of feet on the ground). We propose that the animal extends its stride specifically to improve the duty factor in anticipation of sudden stops of the treadmill belt and that it converts abruptly from diagonal to lateral gait because the extended stride results in collisions between ipsilateral hind and front feet.