[Spontaneous Remission in Chronic Lymphatic Leukemia]

Schweiz Med Wochenschr. 1993 Feb 27;123(8):328-34.
[Article in German]


We describe three patients with chronic lymphocytic leukemia who had a complete spontaneous remission, and review the cases reported in the literature. The mechanism leading to spontaneous remission is unknown, but it is speculated that the loss of a leukemia inducing oncogene or the reappearance of a leukemia suppressor gene could be involved. The interesting observation that, in some reported patients, the remission followed a viral infection, raises the question whether a virus-induced defense mechanism plays a causal role.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Aged
  • Female
  • Genes, Tumor Suppressor
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / physiopathology*
  • Leukocyte Count
  • Lymphocytes
  • Male
  • Neoplasm Regression, Spontaneous*
  • Prognosis
  • Virus Diseases / immunology