Abstract
Upon the addition of methicillin even at relatively low concentrations (5 mug/ml or 0.3% of the MIC) to the medium, methicillin-resistant staphylococci shift to the production of a new peptidoglycan with an abnormal muropeptide composition which may be the synthetic product of penicillin-binding protein 2A.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins*
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Carrier Proteins / physiology*
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Cell Wall / drug effects
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Cell Wall / metabolism*
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Cell Wall / ultrastructure
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Chromatography, High Pressure Liquid
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Hexosyltransferases*
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Methicillin / pharmacology*
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Methicillin Resistance / physiology*
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Microscopy, Electron
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Molecular Sequence Data
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Muramoylpentapeptide Carboxypeptidase / physiology*
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Penicillin-Binding Proteins
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Peptidoglycan / analysis
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Peptidoglycan / biosynthesis*
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Peptidyl Transferases*
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Staphylococcus aureus / metabolism*
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Staphylococcus aureus / ultrastructure
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Substrate Specificity
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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Peptidoglycan
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
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Methicillin