Abstract
The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antimicrobial Cationic Peptides
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Blood Bactericidal Activity*
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Blood Proteins / physiology*
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Complement System Proteins / physiology
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Endotoxins / antagonists & inhibitors*
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Endotoxins / toxicity
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Gram-Negative Bacteria*
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Gram-Negative Bacterial Infections / immunology
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Humans
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Membrane Proteins*
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Models, Biological
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Neutrophils / enzymology
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Neutrophils / physiology*
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Phospholipases / physiology
Substances
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Antimicrobial Cationic Peptides
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Blood Proteins
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Endotoxins
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Membrane Proteins
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bactericidal permeability increasing protein
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Complement System Proteins
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Phospholipases