Abstract
A group of chimeric molecules comprising globular heads, which contain the carbohydrate recognition domain, and collagen tails are defined as collectins. The mannose-binding proteins, pulmonary surfactant apoproteins A and D and conglutinin all qualify as members of this family, whose function appears to be as pattern recognition molecules involved in the first line of defense in the pre-immune host.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Apoproteins
-
Blood Bactericidal Activity
-
Carrier Proteins / chemistry
-
Carrier Proteins / physiology*
-
Collagen / metabolism
-
Collectins*
-
Humans
-
Hyaluronan Receptors*
-
Inflammation
-
Mannose-Binding Lectins
-
Membrane Glycoproteins*
-
Mitochondrial Proteins
-
Molecular Sequence Data
-
Opsonin Proteins / physiology*
-
Pulmonary Surfactants / chemistry
-
Pulmonary Surfactants / physiology*
-
Receptors, Complement / metabolism
-
Serum Globulins / chemistry
-
Serum Globulins / physiology*
Substances
-
Apoproteins
-
C1QBP protein, human
-
Carrier Proteins
-
Collectins
-
Hyaluronan Receptors
-
Mannose-Binding Lectins
-
Membrane Glycoproteins
-
Mitochondrial Proteins
-
Opsonin Proteins
-
Pulmonary Surfactants
-
Receptors, Complement
-
Serum Globulins
-
complement 1q receptor
-
conglutinin
-
Collagen