Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies

Neuroreport. 1993 Jan;4(1):69-72. doi: 10.1097/00001756-199301000-00018.


Transforming growth factor-beta (TGF-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in Alzheimer's disease (AD). In order to examine a possible role of TGF-beta in plaque biogenesis, we studied its distribution in the limbic system of AD and Down's syndrome (DS) brains. Select plaques displayed TGF-beta 1 immunoreactivity in AD and DS. TGF-beta 1 plaques were mainly located in the molecular layer of the dentate gyrus in AD, while in DS TGF-beta 1 plaques were preferentially located in the entorhinal cortex. In AD, TGF-beta 1 immunoreactivity was also shown in neurofibrillary tangles. The presence of TGF-beta 1 in plaques suggests that TGF-beta 1 may play a role in the cascade of events leading to plaque formation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / pathology
  • Down Syndrome / metabolism*
  • Down Syndrome / pathology
  • Extracellular Matrix / metabolism
  • Female
  • Hippocampus / metabolism
  • Hippocampus / pathology
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Transforming Growth Factor beta / immunology
  • Transforming Growth Factor beta / metabolism*


  • Transforming Growth Factor beta