Clinical experience with a hypotonic oral rehydration solution in acute diarrhoea

Acta Paediatr. 1993 Jan;82(1):52-4. doi: 10.1111/j.1651-2227.1993.tb12516.x.


A hypotonic oral rehydration salts (ORS) solution with total osmolality of 224 mosmol/l was compared in an open clinical trial with an isotonic (osmolality 304 mosmol/l) ORS solution for the treatment of dehydration due to acute diarrhoea. Both ORS solutions had the same electrolyte composition with a Na+ concentration of 60 mmol/l. Children given the hypotonic ORS solution (n = 103) passed significantly fewer diarrhoeal stools, and their diarrhoea and hospital stay were shorter than those of children given the isotonic ORS solution (n = 135). We conclude that hypotonic ORS ("light" ORS) has clinical advantages over the standard ORS currently used in Finland.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Acute Disease
  • Diarrhea, Infantile / therapy*
  • Humans
  • Infant
  • Osmolar Concentration
  • Rehydration Solutions*
  • Sodium Chloride / administration & dosage


  • Rehydration Solutions
  • Sodium Chloride