Cyclin D and oncogenesis

Curr Opin Genet Dev. 1993 Feb;3(1):5-10. doi: 10.1016/s0959-437x(05)80334-x.


The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenoma / genetics
  • Breast Neoplasms / genetics
  • Carcinoma, Squamous Cell / genetics
  • Cell Cycle / genetics*
  • Cell Division
  • Cell Transformation, Neoplastic / genetics*
  • Cyclin D1
  • Cyclins / genetics*
  • Cyclins / physiology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Leukemia, B-Cell / genetics
  • Lymphoma, B-Cell / genetics
  • Multigene Family
  • Oncogene Proteins / genetics*
  • Oncogene Proteins / physiology
  • Parathyroid Neoplasms / genetics
  • Proto-Oncogenes*


  • Cyclins
  • Oncogene Proteins
  • Cyclin D1