N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma)

Hum Pathol. 1993 Mar;24(3):294-7. doi: 10.1016/0046-8177(93)90040-n.


Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics
  • Female
  • Ganglioneuroma / genetics*
  • Ganglioneuroma / metabolism
  • Gene Amplification / genetics*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Genes, myc / genetics*
  • Humans
  • Male
  • Neuroblastoma / genetics*
  • Neuroblastoma / metabolism
  • Nucleic Acid Hybridization
  • Prognosis
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism


  • DNA, Neoplasm
  • Proto-Oncogene Proteins c-myc