UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response

J Biol Chem. 1993 Mar 25;268(9):6734-41.


UV irradiated cells release into the culture medium factors that induce, when given to nonirradiated cells, the transcription of several UV-inducible genes (collagenase I, human immunodeficiency virus type 1, metallothionein IIA). We identify here the active factors released from UV-treated HeLa cells, as interleukin 1 alpha and basic fibroblast growth factor. UV irradiation leads to increased mRNA levels for both factors and to their enhanced synthesis. Experiments with the drug suramin, which inhibits growth factor-growth factor receptor interactions and with antibodies directed against interleukin 1 alpha and basic fibroblast growth factor, suggest that growth factors do not only transduce the UV-induced signal to nonirradiated cells but act on the producer cell thus establishing an obligatory growth factor loop for at least part of the UV response.

MeSH terms

  • Antibodies / immunology
  • Blotting, Northern
  • Collagenases / genetics
  • Collagenases / metabolism
  • Culture Media
  • Fibroblast Growth Factor 2 / biosynthesis*
  • Fibroblast Growth Factor 2 / immunology
  • Gene Expression Regulation / radiation effects
  • HeLa Cells
  • Humans
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / immunology
  • Suramin / pharmacology
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / radiation effects
  • Ultraviolet Rays*


  • Antibodies
  • Culture Media
  • Interleukin-1
  • Fibroblast Growth Factor 2
  • Suramin
  • Collagenases