SNAP family of NSF attachment proteins includes a brain-specific isoform

Nature. 1993 Mar 25;362(6418):353-5. doi: 10.1038/362353a0.


The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. Here we report the cloning and sequencing of complementary DNAs encoding alpha-, beta- and gamma-SNAPs. Two of these proteins, alpha and gamma, are found in a wide range of tissues, and act synergistically in intra-Golgi transport. The third, beta, is a brain-specific isoform of alpha-SNAP. Thus, NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused, as described in the accompanying article.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Brain Chemistry*
  • Carrier Proteins / chemistry*
  • Cattle
  • Cloning, Molecular
  • Intracellular Membranes / chemistry
  • Membrane Fusion
  • Mice
  • Molecular Sequence Data
  • N-Ethylmaleimide-Sensitive Proteins
  • Organ Specificity
  • Recombinant Proteins / chemistry
  • Vesicular Transport Proteins*


  • Carrier Proteins
  • Recombinant Proteins
  • Vesicular Transport Proteins
  • N-Ethylmaleimide-Sensitive Proteins
  • Nsf protein, mouse