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, 362 (6418), 355-8

HIV Infection Is Active and Progressive in Lymphoid Tissue During the Clinically Latent Stage of Disease

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HIV Infection Is Active and Progressive in Lymphoid Tissue During the Clinically Latent Stage of Disease

G Pantaleo et al. Nature.

Abstract

Primary infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.

Comment in

  • Viral burden and HIV disease.
    Sheppard HW, Ascher MS, Krowka JF. Sheppard HW, et al. Nature. 1993 Jul 22;364(6435):291-2. doi: 10.1038/364291a0. Nature. 1993. PMID: 8101354 No abstract available.
  • Where the AIDS virus hides away.
    Maddox J. Maddox J. Nature. 1993 Mar 25;362(6418):287. doi: 10.1038/362287a0. Nature. 1993. PMID: 8455711 No abstract available.
  • AIDS. Where has HIV been hiding?
    Temin HM, Bolognesi DP. Temin HM, et al. Nature. 1993 Mar 25;362(6418):292-3. doi: 10.1038/362292a0. Nature. 1993. PMID: 8455713 No abstract available.

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