Relationship between tissue polyamine levels and malignancy in primary brain tumors

Neurosurgery. 1993 Mar;32(3):372-5. doi: 10.1227/00006123-199303000-00006.

Abstract

We studied the relationship between tissue polyamine levels and malignancy in 146 primary brain tumors. Astrocytoma showed a consistent rise in levels of N1-acetylspermidine (N1-AcSpd) in tissue with increased grade of malignancy. Furthermore, in astrocytoma, the patients whose tumors contained high levels of N1-AcSpd (> or = 15 nmol/g) in tissue showed a far worse prognosis, a significantly lower recurrence-free survival rate, and a shorter survival rate than did the patients whose tumors contained lower levels of N1-AcSpd (< 15 nmol/g). High-grade astrocytoma contained N1-AcSpd at the level of 15 nmol/g or higher, and most of the benign brain tumors, including low-grade astrocytoma, meningioma, pituitary adenoma, and normal brain tissues contained much lower levels of N1-AcSpd. However, medulloblastoma, hemangiopericytoma, and neurinoma showed an inverse correlation between N1-AcSpd levels in tissue and biological malignancy. These results suggest that levels of N1-AcSpd in tissue can be a promising biochemical marker of malignancy in astrocytoma. In the other primary brain tumors, however, the relationship between levels of N1-AcSpd in tissue and biological malignancy should be examined in each histopathological type.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism*
  • Brain / pathology
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Polyamines / metabolism*
  • Putrescine / metabolism
  • Spermidine / analogs & derivatives
  • Spermidine / metabolism
  • Spermine / metabolism

Substances

  • Biomarkers, Tumor
  • Polyamines
  • N(1)-acetylspermidine
  • Spermine
  • Spermidine
  • Putrescine