Abstract
Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Antigenic Variation / genetics*
-
Antigens, Fungal / genetics*
-
Candida albicans / genetics*
-
Candida albicans / immunology
-
Candida albicans / pathogenicity
-
Candida albicans / ultrastructure
-
Fungal Proteins / biosynthesis
-
Fungal Proteins / genetics
-
Gene Expression Regulation, Fungal*
-
Phenotype
-
Transcription, Genetic*
-
Virulence
Substances
-
Antigens, Fungal
-
Fungal Proteins