High-frequency phenotypic switching in Candida albicans

Trends Genet. 1993 Feb;9(2):61-5. doi: 10.1016/0168-9525(93)90189-O.


Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigenic Variation / genetics*
  • Antigens, Fungal / genetics*
  • Candida albicans / genetics*
  • Candida albicans / immunology
  • Candida albicans / pathogenicity
  • Candida albicans / ultrastructure
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / genetics
  • Gene Expression Regulation, Fungal*
  • Phenotype
  • Transcription, Genetic*
  • Virulence


  • Antigens, Fungal
  • Fungal Proteins